Distinct Cellular Effects of Myotonic Dystrophy type 2 RAN Tetrapeptides in Drosophila melanogaster
Marta Marzullo, Assia De Simone, Marta Terribili, Michela Di Salvio, Degisew Yinur Mengistu, Maria Patrizia Somma, Rodrigo D'Amico, Gianluca Canettieri, Gianluca Cestra, Laura Ciapponi
This study investigates the distinct toxic effects of QAGR and PACL peptides in Drosophila, showing they impair nucleolar function and autophagy or alter stress granule dynamics, contributing to DM2 pathogenesis.
Disease Models & Mechanisms · Apr 20, 2026Peer-reviewedGenetics