Laura Ciapponi

This study investigates the distinct toxic effects of QAGR and PACL peptides in Drosophila, showing they impair nucleolar function and autophagy or alter stress granule dynamics, contributing to DM2 pathogenesis.

This study identifies Caspase-8 as a novel promoter of Homologous Recombination Repair in glioblastoma, enhancing DNA repair and resistance to ionizing radiation.

This study shows that asp and Sas4 genes in Drosophila affect nuclear structure, chromatin organization, and genome stability, contributing to microcephaly pathogenesis.

The paper shows that Su(var)3-9 increases H3K9 methylation on the TDP-43 promoter with age, leading to reduced TDP-43 expression and neurodegeneration in Drosophila, mice, and humans.

The paper uses spatially resolved transcriptomics to identify innervation-responsive functional clusters in skeletal muscle and shows changes in atrophic signaling and polyamine metabolism upon denervation.

The paper shows that low-dose rate γ-irradiation reduces chromosome breaks and telomere fusions in Drosophila by modulating Loquacious expression.

The paper identifies cell- and stage-specific transcriptional signatures in Drosophila neurons, glia, and hemocytes, revealing that developmental stage significantly influences gene expression patterns.

This paper shows that depletion of Drosophila CNBP causes age-dependent locomotor defects linked to reduced polyamine metabolism and ODC levels, which can be rescued by polyamine supplementation or ODC overexpression.

This study identifies functional interactions between TGS1 and the Smn complex in Drosophila eye development, showing their roles in retinal progenitor cell viability and eye size.