Tertiary lymphoid structure as a therapeutic target of Crohns disease: modulation by TNFα blockade
Yoshihiro Nagase, Soh Okano, Asuka Furukawa, Takumi Kanazawa, Kouhei Yamamoto, Kurara Yamamoto, Kenichi Ohashi, Tetsuo Yamana, Shuko Nojiri, Yutaka Suzuki, Akinori Kanai, Takashi Yao, Keiko Abe, Toshiaki Ohteki, Makoto Kodama
This study shows that TNF inhibitor infliximab reduces tertiary lymphoid structures and alleviates Crohn's disease inflammation by targeting follicular dendritic cells and macrophages.
bioRxiv · Nov 23, 2024 · PreprintImmunology