Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer's disease cognition
Noah R. Johnson, Athena C.-J. Wang, Christina M. Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil E. Markham, Cody Allen, A. Ranjitha Dhanasekaran, Heidi J. Chial, Huntington Potter
The paper identifies imipramine and olanzapine as inhibitors of apoE4-catalyzed Aβ polymerization, showing cognitive improvements in Alzheimer's patients.
bioRxiv · Mar 28, 2021 · PreprintNeuroscience