Christina M. Coughlan

This study shows that trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apoE co-pathologies, with apoE playing a key role in the disease process.

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

The paper investigates how alpha-synuclein regulates CD81 in melanoma, showing their correlation with immune suppression and tumor progression.

The paper investigates the binding of Alzheimer's Aβ peptides to exosomes using ITC, finding specific interactions that suggest exosomes as a significant reservoir of these peptides in plasma.

The paper identifies imipramine and olanzapine as inhibitors of apoE4-catalyzed Aβ polymerization, showing cognitive improvements in Alzheimer's patients.