Huntington Potter

This study uses microglia-containing Alzheimer's disease brain organoids to monitor Aβ aggregation and cellular viability, identifying age-dependent disease-associated phenotypes.

This study shows that trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apoE co-pathologies, with apoE playing a key role in the disease process.

This study investigates how traumatic brain injury (TBI) affects Alzheimer's disease (AD) pathology in the retinas of a transgenic rat model, finding that TBI exacerbates AD-related histopathology.

This study shows that overexpressing Kif11 rescues cognitive and synaptic deficits in Alzheimer's disease models.

The paper investigates the binding of Alzheimer's Aβ peptides to exosomes using ITC, finding specific interactions that suggest exosomes as a significant reservoir of these peptides in plasma.

The paper identifies imipramine and olanzapine as inhibitors of apoE4-catalyzed Aβ polymerization, showing cognitive improvements in Alzheimer's patients.