Noah R. Johnson

This study shows imipramine binds to amyloid-β, reduces Aβ accumulation, and improves survival in Alzheimer's patients.

This study uses microglia-containing Alzheimer's disease brain organoids to monitor Aβ aggregation and cellular viability, identifying age-dependent disease-associated phenotypes.

The paper shows imipramine binds to A{beta}(1-42) monomers in vitro using NMR spectroscopy, but not to A{beta}(1-40).

This study shows that trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apoE co-pathologies, with apoE playing a key role in the disease process.

This study investigates how traumatic brain injury (TBI) affects Alzheimer's disease (AD) pathology in the retinas of a transgenic rat model, finding that TBI exacerbates AD-related histopathology.

This study shows that overexpressing Kif11 rescues cognitive and synaptic deficits in Alzheimer's disease models.

The paper identifies imipramine and olanzapine as inhibitors of apoE4-catalyzed Aβ polymerization, showing cognitive improvements in Alzheimer's patients.