Widespread shortening of 3’ untranslated regions and increased exon inclusion are evolutionarily conserved features of innate immune responses to infection
Athma A Pai, Golshid Baharian, Ariane Page Sabourin, Jessica F Brinkworth, Yohann Nedelec, Joseph W Foley, Jean-Christophe Grenier, Katherine J Siddle, Anne Dumaine, Vania Yotova, Zachary P Johnson, Robert E Lanford, Christopher B Burge, Luis B Barreiro
The paper identifies widespread changes in RNA processing, including shorter 3’ UTRs and increased exon inclusion, in innate immune responses across humans and non-human primates.
PLOS Genetics · Sep 30, 2016Peer-reviewedGenomics