Author

Jean-Christophe Grenier

Primary ORCID profile (0000-0001-7937-5160 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Jean-Christophe GrenieriD1 paper · Montreal Heart Institute;

Biology Disciplines

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Genomics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anne Dumaine· 2 shared Vania YotovaiD· 2 shared Alain PacisiD· 1 shared Alan HodgkinsoniD· 1 shared Anne Danckaert· 1 shared Ariane Page Sabourin· 1 shared Athma A Pai· 1 shared Athma Pai· 1 shared

Activity by Year

2014-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Anne Dumaine

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Author profile →

3 papers

Recent·Most cited

Widespread shortening of 3’ untranslated regions and increased exon inclusion are evolutionarily conserved features of innate immune responses to infection

Athma A Pai, Golshid Baharian, Ariane Page Sabourin, Jessica F Brinkworth, Yohann Nedelec, Joseph W Foley, Jean-Christophe Grenier, Katherine J Siddle, Anne Dumaine, Vania Yotova, Zachary P Johnson, Robert E Lanford, Christopher B Burge, Luis B Barreiro

The paper identifies widespread changes in RNA processing, including shorter 3’ UTRs and increased exon inclusion, in innate immune responses across humans and non-human primates.

PLOS Genetics · Sep 30, 2016Peer-reviewedGenomics

Bacterial Infection Remodels the DNA Methylation Landscape of Human Dendritic Cells

Alain Pacis, Ludovic Tailleux, John Lambourne, Vania Yotova, Anne Dumaine, Anne Danckaert, Francesca Luca, Jean-Christophe Grenier, Kasper Hansen, Brigitte Gicquel, Miao Yu, Athma Pai, Jenny Tung, Chuan He, Tomi Pastinen, , Luis Barreiro

This study shows that bacterial infection rapidly alters DNA methylation in human dendritic cells, affecting enhancer elements and gene expression related to immune responses.

Genome Research · Sep 21, 2015Peer-reviewedGenomics

Recombination impacts damaging and disease mutation accumulation in human populations

Julie Hussin, Alan Hodgkinson, Youssef Idaghdour, Jean-Christophe Grenier, Jean-Philippe Goulet, Elias Gbeha, Elodie Hip-Ki, Philip Awadalla

The paper shows that recombination rate influences the distribution of deleterious variants across the human genome, with low recombination regions enriched for disease-associated mutations.

bioRxiv · Sep 10, 2014Evolutionary Biology