Small-molecule modulators of HIPK4 activity and proteostasis
Zaile Zhuang, Riley K. Togashi, Patrick C. Kearney, Ian Pass, Steven M. Swick, Fu‐Yue Zeng, Andrey A. Bobkov, Lynn Miya Fujimoto, Shubhankar Dutta, Athina Zerva, Nicolai D. Raig, Debasmita Saha, Atoosa Emami, Martin P. Schwalm, Bradley K. Moon, , James Chen
This study identifies cyanoquinoline-based HIPK4 inhibitors with nanomolar potency and reveals their cell-type-specific effects on HIPK4 proteostasis and autophagy.
Journal of the American Chemical Society · Oct 5, 2026Peer-reviewedBiochemistry