Integrin beta 1 and mannose receptor 2 are involved in the antifungal activity of bronchial epithelial cells through Aspergillus fumigatus lectin FleA interactions
Nicolas Millet, Audrey Moreau, Marine Tarizzo, Léa Marti, Annabelle Varrot, Émilie Gillon, Nicolas Richard, Cédric Pionneau, Solenne Chardonnet, Hugo Varet, Romain Morichon, J. Guitard, Loïc Guillot, Viviane Balloy, Jeanne Bigot
This study identifies ITGB1 and MRC2 as host factors involved in bronchial epithelial cell antifungal activity through interactions with A. fumigatus lectin FleA, revealing two pathways that inhibit fungal filamentation.
bioRxiv · Feb 27, 2026 · PreprintCell Biology