Jeanne Bigot

Integrin beta 1 and mannose receptor 2 are involved in the antifungal activity of bronchial epithelial cells through Aspergillus fumigatus lectin FleA interactions

This study identifies ITGB1 and MRC2 as host factors involved in bronchial epithelial cell antifungal activity through interactions with A. fumigatus lectin FleA, revealing two pathways that inhibit fungal filamentation.

Hijacking of inflammasome responses by the complement system during Pseudomonas aeruginosa-Aspergillus fumigatus sur-infection

This study identifies a complement-inflammasome signaling axis that drives excessive inflammation during Pseudomonas aeruginosa and Aspergillus fumigatus co-infection in cystic fibrosis patients.

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

The paper identifies an epigenetic mechanism in bronchial epithelial cells that enables trained immunity through chromatin remodeling and gene expression changes following flagellin exposure.

New insights into the echinocandin resistance in Candida spp. in the clinical setting

The paper investigates echinocandin resistance in Candida species, finding that increased consumption did not lead to significant resistance, but mutations in glucan synthase genes affect fitness differently across species.