Nicolas Millet

Non-canonical IL-22 receptor signaling remodels the mucosal barrier during fungal immunosurveillance

This study shows that fungal-induced immunosurveillance remodels the oral mucosal barrier via a non-canonical IL-22 receptor complex, enhancing resistance to Candida albicans colonization.

Integrin beta 1 and mannose receptor 2 are involved in the antifungal activity of bronchial epithelial cells through Aspergillus fumigatus lectin FleA interactions

This study identifies ITGB1 and MRC2 as host factors involved in bronchial epithelial cell antifungal activity through interactions with A. fumigatus lectin FleA, revealing two pathways that inhibit fungal filamentation.

Synergistic cross-kingdom host cell damage between Candida albicans and Enterococcus faecalis

This study shows that Candida albicans and Enterococcus faecalis synergistically increase host cell damage through physical interaction and glucose depletion.

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

The paper identifies an epigenetic mechanism in bronchial epithelial cells that enables trained immunity through chromatin remodeling and gene expression changes following flagellin exposure.

Metabolic imprinting drives epithelial memory during mucosal fungal infection

This study identifies a metabolic-epigenetic mechanism in oral epithelial cells that enhances protection against fungal infection through proline catabolism and mitochondrial function.