Sequence-directed covalent protein-RNA linkages using engineered HUH-Tags
Adam T. Smiley, Calvin J Thoma, Natalia S. Babilonia-Díaz, August J. Krueger, Andrew C.D. Lemmex, Aspen J Hughes, Matthew R Pawlak, Kassidy J. Tompkins, Robert P Connacher, Hideki Aihara, Wendy Ryan Gordon
This study engineers HUH-tags to form sequence-directed covalent bonds with RNA, enhancing their reactivity through directed evolution.
Nucleic Acids Research · May 13, 2026Peer-reviewedBiochemistry