Matthew R. Pawlak

This paper introduces programmable antibody-DNA conjugation methods using HUH-tags to enable quantitative measurement of receptor-specific adhesion dynamics in cancer cells and NK cells.

This paper demonstrates the use of a non-cytotoxic aerolysin mutant to non-genetically functionalize cell surfaces with proteins, enzymes, and DNA.

This study engineers HUH-tags to form sequence-directed covalent bonds with RNA, enhancing their reactivity through directed evolution.

This paper develops a DNA-based tension sensor platform to measure mechanical forces in cells, enabling direct quantification of drug-induced changes in force transmission for mechanotherapeutic discovery.

This study demonstrates the controlled exchange of protein and nucleic acid signals between synthetic minimal cells using cell penetrating peptides.

This paper demonstrates a DNA nanodevice that switches between catalytic and non-catalytic electron transfer states using a chaotropic ion.