Andrew C.D. Lemmex

This paper introduces programmable antibody-DNA conjugation methods using HUH-tags to enable quantitative measurement of receptor-specific adhesion dynamics in cancer cells and NK cells.

This paper demonstrates the use of a non-cytotoxic aerolysin mutant to non-genetically functionalize cell surfaces with proteins, enzymes, and DNA.

This study engineers HUH-tags to form sequence-directed covalent bonds with RNA, enhancing their reactivity through directed evolution.

This study develops a Notch inhibitory nanobody and demonstrates a strategy to enhance its efficacy through fusion with an Aerolysin domain.

HUHgle is a tool for designing and optimizing HUH-tag mediated protein-ssDNA conjugates, predicting formation efficiency and specificity.

This paper describes a split Staphylococcus aureus prime editor delivered by dual AAVs, demonstrating in vitro editing capacity despite lower-than-ideal efficiency.