Mesenchymal stromal cells release CXCL1/2/8 and induce chemoresistance and macrophage polarization
Bettina Couderc, Augustin Le Naour, Mélissa Prat, Renaud Mevel, Benoit Thibault, Lea Lemaitre, Helene Leray, Muriel Golzio, Lise Lefevre, Eliane Mery, Alejandra Martinez, Gwenael Ferron, Jean-Pierre Delord, Agnès Coste
This study identifies CXCL1/2/8 as factors released by cancer-associated mesenchymal stromal cells that induce chemoresistance and macrophage polarization, suggesting CXCR1/2 inhibition as a potential therapeutic strategy.
bioRxiv · Dec 4, 2018 · PreprintCancer Biology