The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the α-Gal antigen
Benjamin B. A. Raymond, Tamara Sneperger, Stella Rousset, Nelly Gilles, Aurélie Bally, Alexandre Stella, Agnes L. Hipgrave Ederveen, Julien Marcoux, Giulia Trimaglio, Michel Thépaut, Frédéric Lagarrigue, Odile Burlet‐Schiltz, Manfred Wuhrer, Franck Fieschi, Pascal Demange, , Yoann Rombouts
This study identifies LRP1 N-glycans with terminal galactoses as ligands for DCIR, revealing its specificity in immune regulation and potential therapeutic applications.
bioRxiv · May 20, 2024 · PreprintImmunology