Cardiomyocyte pyruvate dehydrogenase kinase 1 knockout activates Rho-mediated remodeling and decreases fatty acyl availability in female mice
Michael G. Atser, Sareh Panahi, Justin J. Hong, Xiaoke Hu, Aura Balita, Haoning Howard Cen, Sing-Young Chen, Vincent R. Richard, Timon Geib, Armando Alcázar Magaña, Brian B. Rodrigues, Leonard J. Foster, Elizabeth J. Rideout, Christoph H. Borchers, James D. Johnson
This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.
bioRxiv · Jul 31, 2026 · PreprintMolecular Biology