Xiaoke Hu

This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.

The paper shows that lowering insulin levels in mice prevents reproductive aging and diet-induced ovarian dysfunction, linking hyperinsulinemia to subfertility.

The paper identifies Ins2 gene activity states in beta cells and shows that cAMP activators drive transitions between these states.

This study shows that reducing endogenous insulin production decreases pancreatic cancer precursors in mice, suggesting insulin hypersecretion contributes to pancreatic cancer development.