Haoning Howard Cen

This study shows tamoxifen reduces subcutaneous adipocyte progenitor self-renewal and adipogenesis by suppressing Wisp2, linking endocrine therapy to metabolic risks like T2D.

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.

This study shows that loss of brain insulin production in female mice impairs learning and memory, while having no effect on males.

This study examines sex differences in human islet gene expression and mitochondrial function in type 2 diabetes, finding female islets show greater preservation of insulin content and fewer functional defects.

This study identifies ETV4 as a mediator of FGF1-driven proliferation and glycolysis in ER-positive breast cancer, linking obesity-related FGF1 production to tumor progression.

This study shows that PDK1 regulates triacylglycerol turnover in cardiomyocytes under nutrient deprivation, independent of its role in glucose metabolism.

The paper identifies Ins2 gene activity states in beta cells and shows that cAMP activators drive transitions between these states.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.