Sing-Young Chen

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.

This study examines sex differences in human islet gene expression and mitochondrial function in type 2 diabetes, finding female islets show greater preservation of insulin content and fewer functional defects.

The paper identifies fibroblast growth factors (FGFs) as protective for human stem cell-derived insulin-secreting beta cells through a medium-throughput screen.