James D. Johnson

This study shows that endogenous insulin in pancreatic cancer tumors affects tumor growth and systemic metabolism, with differential effects based on diet and mouse sex.

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

This study shows that PDK1 knockout in female mice leads to cardiac metabolic remodeling and reduced fatty acyl availability, while male mice show no such effects.

This study shows that loss of brain insulin production in female mice impairs learning and memory, while having no effect on males.

This study shows psilocybin reduces established aversive sensory representations in the mouse auditory cortex without affecting new aversive learning or general auditory processing.

This study examines sex differences in human islet gene expression and mitochondrial function in type 2 diabetes, finding female islets show greater preservation of insulin content and fewer functional defects.

The paper shows that lowering insulin levels in mice prevents reproductive aging and diet-induced ovarian dysfunction, linking hyperinsulinemia to subfertility.

This study shows that PDK1 regulates triacylglycerol turnover in cardiomyocytes under nutrient deprivation, independent of its role in glucose metabolism.

The paper identifies Ins2 gene activity states in beta cells and shows that cAMP activators drive transitions between these states.

The paper identifies fibroblast growth factors (FGFs) as protective for human stem cell-derived insulin-secreting beta cells through a medium-throughput screen.

This study shows senolytics like ABT-263 restore bone marrow function in sickle cell disease by reversing HSC dysfunction and senescence in mice.

The paper infers post-transcriptional regulatory mechanisms in human islets using cell type-specific eQTLs from single-cell RNA-seq data, linking variants to biological processes in health and disease.

This study shows that β-hydroxybutyrate (βHB) increases insulin secretion and decreases glucagon secretion in human and mouse islets at physiological glucose concentrations.

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

The paper presents a method to identify disulphide-bonded insulin forms using thermolysin cleavage and LC-MS/MS, revealing aberrant species linked to diabetes.

This study tracks synapse plasticity in tauopathy and finds that changes in synaptic structure precede neurite degeneration, with distinct patterns in axons and dendrites.

The paper investigates how mitochondrial positioning affects the stability of presynaptic boutons in mouse neocortex, finding that mitochondrial localization correlates with increased bouton stability over time.