Coordinated CAII and CAIV establish a dual pH-regulatory axis essential for CatSper activation during sperm maturation and capacitation
Caroline Wiesehöfer, Cameron C. Gardner, Aura Stoskus, María Agustina Battistone, Gunther Wennemuth, Jean‐Ju Chung
This study shows that coordinated CAII and CAIV pH regulation is essential for sperm motility by establishing dual-compartment pH environments that activate CatSper channels.
bioRxiv · Oct 13, 2025 · PreprintCell Biology