Author

Caroline Wiesehöfer

University of Duisburg-EssenORCID 0000-0002-7174-9954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Gunther WennemuthiD· 2 shared Jean‐Ju ChungiD· 2 shared Aura Stoskus· 1 shared Cameron C. GardneriD· 1 shared Jong‐Nam OhiD· 1 shared Lara Suetin· 1 shared Layani Chandrakumar· 1 shared Lorena Sunjic· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Gunther WennemuthORCID

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2 papers

Recent·Most cited

Soluble ZP2 N-terminal fragments activate CatSper-dependent Ca2+ entry and regulate motility and acrosomal exocytosis in mammalian sperm

Caroline Wiesehöfer, Lorena Sunjic, Lara Suetin, Jong‐Nam Oh, Marc Wiesehoefer, Mykola Lyndin, Thiviya Thayaparan, Layani Chandrakumar, Jean‐Ju Chung, Gunther Wennemuth

This study identifies soluble ZP2 N-terminal fragments as activators of CatSper-dependent Ca2+ entry, regulating sperm motility and acrosomal exocytosis in mice and humans.

bioRxiv · Aug 20, 2026 · PreprintCell Biology

Coordinated CAII and CAIV establish a dual pH-regulatory axis essential for CatSper activation during sperm maturation and capacitation

Caroline Wiesehöfer, Cameron C. Gardner, Aura Stoskus, María Agustina Battistone, Gunther Wennemuth, Jean‐Ju Chung

This study shows that coordinated CAII and CAIV pH regulation is essential for sperm motility by establishing dual-compartment pH environments that activate CatSper channels.

bioRxiv · Oct 13, 2025 · PreprintCell Biology