Rspo1 dependent WNT signaling safeguards ovarian development by suppressing androgen signaling
Furong Tang, Natividad Bellido-Carreras, Kheira Bouzid, Aurélie Lardenois, Thomas Darde, Magali Dhellemmes, Aurelie Despoux, Mirko Peitzsch, Marie‐Christine Birling, Frédéric Chalmel, Marie‐Christine Chaboissier, Aitana Perea-Gómez
This study shows RSPO1/WNT/B-catenin signaling suppresses androgen signaling during ovarian development in mice, with androgen receptor inhibition rescuing development in mutants.
bioRxiv · Sep 23, 2026 · PreprintDevelopmental Biology