Mirko Peitzsch

This study shows RSPO1/WNT/B-catenin signaling suppresses androgen signaling during ovarian development in mice, with androgen receptor inhibition rescuing development in mutants.

This paper identifies transient GSK3β activation as a mechanism promoting disease tolerance to sepsis through hypometabolism, without affecting pathogen burden.

This study shows ACOD1 deficiency in microglia enhances inflammatory responses by altering arginine metabolism, specifically increasing argininosuccinate synthesis while reducing polyamine synthesis, dependent on ACLY.

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

This study uses patient-derived organoids to model pheochromocytomas and paragangliomas, revealing hypoxia-driven plasticity and therapeutic vulnerabilities, including responses to abemaciclib.

This study identifies AZIN2 as a regulator of adipocyte progenitor fate through polyamine metabolism, showing its protective role against obesity and metabolic dysfunction.

This study shows that glutamine transporters regulate prostate cancer radiosensitivity via NUPR1-mediated stress response, with targeting these transporters enhancing radiosensitivity and improving treatment outcomes.

This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.

This study investigates how HIF1α regulates steroidogenesis under acute hypoxia using cell lines, ex vivo models, and mice, finding HIF1α-dependent miRNA regulation and translational control of steroidogenic enzymes.

This paper identifies a novel molecular subtype of papillary renal cell carcinoma (pRCC) characterized by HIF-pathway overactivation, associated with poor prognosis and distinct biological features.

This study develops a step-wise in vitro differentiation system from mouse embryonic stem cells into glucocorticoid-producing adrenocortical cells using fibronectin and cAMP activators.

This study shows that PHD2-HIF2 pathway regulates epinephrine synthesis and release in mouse adrenal glands, linking hypoxia signaling to catecholamine production and systemic glucose levels.

This study shows HIF1α is crucial for steroid hormone production in adrenal cells, with its absence increasing steroid levels and overexpression reducing them, affecting systemic health.