Frédéric Chalmel

Rspo1 dependent WNT signaling safeguards ovarian development by suppressing androgen signaling

This study shows RSPO1/WNT/B-catenin signaling suppresses androgen signaling during ovarian development in mice, with androgen receptor inhibition rescuing development in mutants.

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologies

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

Genome-wide transcriptional silencing and mRNA stabilization allow the coordinated expression of the meiotic program in mice

The paper quantifies transcriptional dynamics in mouse spermatogonia during meiosis, identifying a transcriptional slowdown and mRNA stabilization event that coordinates meiotic gene expression.

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

This study examines how gender-affirming hormone therapy affects the spermatogonial stem cell niche in trans women, finding partial rejuvenation of somatic cells and fibrotic changes.

Single-cell transcriptome landscape of developing fetal gonads defines somatic cell lineage specification in humans

The paper maps the single-cell transcriptome of human fetal gonads to define somatic cell lineage specification during development.

Microenvironment of metastasis reveals key predictors of PD-1 blockade response in renal cell carcinoma

The paper identifies key predictors of PD-1 blockade response in renal cell carcinoma by analyzing the tumor microenvironment of metastatic sites and developing a predictive TID score.

Loss of NR5A1 in Sertoli cells after sex determination changes their cellular identity and induces their death by anoikis

This study shows that loss of NR5A1 in Sertoli cells after sex determination leads to their transdifferentiation, anoikis, and testis abnormalities.

Androglobin, a chimeric mammalian globin, is required for male fertility

This study identifies androglobin (Adgb) as essential for male fertility in mice, showing its role in spermatogenesis and flagellum formation through interactions with Sept10.

FlexDotPlot: a universal and modular dot plot visualization tool for complex multifaceted data

FlexDotPlot is an R package that generates dot plots for multifaceted data, including single-cell RNA-seq, with an interactive Shiny app for non-R users.

The Male Fertility Gene Atlas - A web tool for collecting and integrating data about epi-/genetic causes of male infertility

The Male Fertility Gene Atlas aggregates and integrates OMICs data from publications on male infertility to enable targeted search and meta-analysis of genetic and epigenetic factors.

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

The paper identifies RUNX1 as a conserved regulator of fetal ovarian supporting cell identity, showing its interaction with FOXL2 in maintaining granulosa cell fate across species.