Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses
Darryl Adelaide Abbott, Ali T. Rai, Aaron Yang, Yixuan Cai, Shelcie Fabre, Austin J. Frazer, Jacob D. DeSchepper, Amanda C. Poholek, Timothy Wesley Hand
This study shows that maternal IgA suppresses Enterobacteriaceae colonization and prevents the development of intestinal microbiota-specific CD4+ T cells in neonates.
bioRxiv · Jun 10, 2024 · PreprintImmunology