Amanda C. Poholek

A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation

This study identifies a core gene program underlying Tfh cell differentiation using a multi-scale network systems approach, revealing a novel role for IL-12 in regulating Tfh precursor differentiation.

AMPK agonism optimizes the in vivo persistence and anti-leukemia efficacy of chimeric antigen receptor T cells

This study shows that activating AMPK during CAR T cell expansion improves their in vivo persistence and anti-leukemia efficacy without altering expansion protocols or genetic constructs.

Characterizing spatial functional microniches with SpaceTravLR

SpaceTravLR identifies spatial functional microniches by modeling genetic perturbations across spatially resolved molecular networks, validated experimentally in a murine model.

Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses

This study shows that maternal IgA suppresses Enterobacteriaceae colonization and prevents the development of intestinal microbiota-specific CD4+ T cells in neonates.

SLIDE: Significant Latent Factor Interaction Discovery and Exploration across biological domains

SLIDE identifies significant interacting latent factors in multi-omic datasets, revealing biological insights in systemic sclerosis, spatial transcriptomics, and T1D models.