PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor
Patricia D.B. Tiburcio, Kavita K. Desai, Austin Warne, Arash Nabbi, Serena Zhou, Sean D. Reiff, Matthew E. Campbell, James F. Amatruda, Kenneth Sung-Man Chen
This study identifies factors regulating PD-L1 expression in Wilms tumor, showing chemotherapy, Wnt/β-catenin signaling, and mutations in CTNNB1 and DROSHA correlate with increased PD-L1 levels.
Pediatric Blood & Cancer · Jun 13, 2025Peer-reviewedCancer Biology