Kavita K. Desai

This study identifies factors regulating PD-L1 expression in Wilms tumor, showing chemotherapy, Wnt/β-catenin signaling, and mutations in CTNNB1 and DROSHA correlate with increased PD-L1 levels.

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.