Patricia D.B. Tiburcio

This study identifies factors regulating PD-L1 expression in Wilms tumor, showing chemotherapy, Wnt/β-catenin signaling, and mutations in CTNNB1 and DROSHA correlate with increased PD-L1 levels.

This study shows that actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor, sensitizing anaplastic cells to treatment and improving survival in xenograft models.