James F. Amatruda

Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm

This study identifies neural crest cells as the origin of Ewing sarcoma by developing a zebrafish model and showing EWSR1::FLI1 reprograms these cells to a mesoderm-like state.

PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor

This study identifies factors regulating PD-L1 expression in Wilms tumor, showing chemotherapy, Wnt/β-catenin signaling, and mutations in CTNNB1 and DROSHA correlate with increased PD-L1 levels.

Robust statistical assessment of Oncogenotype to Organotropism translation in xenografted zebrafish

This paper develops an imaging-based assay using zebrafish larvae to assess organotropism of cancer xenografts and identifies EWSR1::FLI1 and SOX6 as plasticity factors enhancing metastatic adaptability.

Tumor-associated stroma shapes the spatial tumor immune microenvironment of primary Ewing sarcomas

This study uses spatial transcriptomics to analyze Ewing sarcoma tumors, finding that localized tumors have more stromal enrichment and unique immune signals compared to metastatic tumors.

Caveolin-1 regulates context-dependent signaling and survival in Ewing Sarcoma.

This study identifies Caveolin-1 as a context-dependent regulator of survival signaling in Ewing Sarcoma, revealing a reversible CD99High state with enhanced survival.

GCNA preserves genome integrity and fertility across species

The paper identifies GCNA as a conserved regulator of genome stability in germ cells across species, showing its role in preventing DNA damage and maintaining fertility.