Lysine 117 on ataxin-3 modulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
Jessica R. Blount, Nikhil C. Patel, Kozeta Libohova, Autumn L. Harris, Wei‐Ling Tsou, Alyson L. Sujkowski, Sokol V. Todi
This study investigates the role of lysine 117 ubiquitination in modulating toxicity of pathogenic Atxn3 in Drosophila models of SCA3, finding that mutating K117 mildly enhances toxicity and aggregation.
bioRxiv · May 30, 2023 · PreprintNeuroscience