Sokol V. Todi

This study shows that mutating SUMOylation sites in the androgen receptor in Drosophila models of SBMA improves longevity but has limited effects on motor performance.

This study identifies tissue-specific proteomic changes in a Drosophila SCA17 model, showing polyglutamine-expanded TBP affects pathways beyond transcription.

This study investigates how chronic alpha-synuclein over-expression and ceruloplasmin-mediated iron modulation affect iron and redox homeostasis in neuroblastoma cells.

This study uses RNA-seq to analyze transcriptomic changes in HEK293T cells with mutant Atrophin-1, identifying disruptions in multiple pathways linked to DRPLA pathology.

This study shows that manipulating polyamine interconversion enzymes in a Drosophila Parkinson's model affects alpha-synuclein levels and toxicity, suggesting a potential therapeutic target.

This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.

The paper investigates how linear ubiquitin chains affect the proteome in Drosophila by analyzing proteomic changes in flies expressing chains of different lengths.

This paper develops a Drosophila model of SBMA by expressing human AR with pathogenic polyQ repeats, showing motor neuron degeneration and aggregation linked to androgen dependence.

This paper develops new Drosophila models of SCA7 with polyQ repeats, showing age- and repeat-length-dependent neurodegeneration and protein aggregation.

This study introduces two new Drosophila models expressing human TBP with polyQ repeats to study SCA17 pathology and its effects on neurodegeneration.

This study investigates the role of lysine 117 ubiquitination in modulating toxicity of pathogenic Atxn3 in Drosophila models of SCA3, finding that mutating K117 mildly enhances toxicity and aggregation.

The paper investigates how wild-type and pathogenic ATXN3 affect ubiquitination levels in different brain regions and ages in SCA3 models.

This study shows endurance exercise reduces motor dysfunction and extends lifespan in Drosophila models of SCA2 and SCA6, but not SCA3, through mechanisms involving Sestrin and autophagy.

The paper identifies 15 druggable genes that modulate ATXN3 levels and toxicity in SCA3, with FBXL3/SCF pathway showing potential as a therapeutic target.