Wei‐Ling Tsou

This study investigates how chronic alpha-synuclein over-expression and ceruloplasmin-mediated iron modulation affect iron and redox homeostasis in neuroblastoma cells.

This study identifies a bidirectional relationship between the SAGA complex deubiquitinase module and the molecular circadian clock, showing mutual regulation of their activities.

This study shows that manipulating polyamine interconversion enzymes in a Drosophila Parkinson's model affects alpha-synuclein levels and toxicity, suggesting a potential therapeutic target.

This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.

This paper develops new Drosophila models of SCA7 with polyQ repeats, showing age- and repeat-length-dependent neurodegeneration and protein aggregation.

This study investigates the role of lysine 117 ubiquitination in modulating toxicity of pathogenic Atxn3 in Drosophila models of SCA3, finding that mutating K117 mildly enhances toxicity and aggregation.