Alyson L. Sujkowski

This paper develops a Drosophila model of SBMA by expressing human AR with pathogenic polyQ repeats, showing motor neuron degeneration and aggregation linked to androgen dependence.

This paper develops new Drosophila models of SCA7 with polyQ repeats, showing age- and repeat-length-dependent neurodegeneration and protein aggregation.

This study introduces two new Drosophila models expressing human TBP with polyQ repeats to study SCA17 pathology and its effects on neurodegeneration.

This study investigates the role of lysine 117 ubiquitination in modulating toxicity of pathogenic Atxn3 in Drosophila models of SCA3, finding that mutating K117 mildly enhances toxicity and aggregation.

This study shows endurance exercise reduces motor dysfunction and extends lifespan in Drosophila models of SCA2 and SCA6, but not SCA3, through mechanisms involving Sestrin and autophagy.