MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer's disease
Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Zeynep Sarica, Rita O’Rourke, Sarah Herrick, Avery Davis, Dylan T. Garceau, Michael Sasner, Gregory W. Carter, Gareth R. Howell
The paper shows that the MTHFR*677C>T variant in a mouse model of LOAD produces distinct transcriptional and proteomic signatures related to cerebrovascular and synaptic biology.
bioRxiv · Aug 28, 2026 · PreprintNeuroscience