Kevin P. Kotredes

The paper shows that the MTHFR*677C>T variant in a mouse model of LOAD produces distinct transcriptional and proteomic signatures related to cerebrovascular and synaptic biology.

This study shows that human KL haplotypes FC and VS cause widespread transcriptomic changes in mouse brains at 12 months old, affecting mitochondrial, ribosomal, and synaptic functions, and linking them to Alzheimer's Disease pathogenesis.

This study compares two mouse models of TREM2 variants, showing both mimic Alzheimer's disease signatures in similar biological domains.

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

This study shows that a high fat-high sugar diet interacts with the Plcg2M28L genetic variant to accelerate Alzheimer's disease-like phenotypes in mice.

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

This study identifies unique gene signatures in the cortex of young mice with APOEε3/ε4 and APOEε4/ε4 genotypes, showing distinct transcriptomic and functional differences.