Author

Rita O’Rourke

Jackson Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gareth R. HowelliD· 3 shared Dylan T. Garceau· 2 shared Gregory W. CarteriD· 2 shared Kevin P. KotredesiD· 2 shared Michael SasneriD· 2 shared Ravi S. PandeyiD· 2 shared Sarah Herrick· 2 shared Adrian L. OblakiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Gareth R. HowellORCID

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Author profile →

3 papers

Recent·Most cited

MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer's disease

Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Zeynep Sarica, Rita O’Rourke, Sarah Herrick, Avery Davis, Dylan T. Garceau, Michael Sasner, Gregory W. Carter, Gareth R. Howell

The paper shows that the MTHFR*677C>T variant in a mouse model of LOAD produces distinct transcriptional and proteomic signatures related to cerebrovascular and synaptic biology.

bioRxiv · Aug 28, 2026 · PreprintNeuroscience

Characterizing Molecular and Synaptic Signatures in Mouse Models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology

Kevin P. Kotredes, Ravi S. Pandey, Scott A. Persohn, Kierra Elderidge, Charles P. Burton, Ethan W. Miner, Kathryn A. Haynes, Diogo Francisco da Silva dos Santos, Sean‐Paul Gerard Williams, Nicholas Heaton, Cynthia M. Ingraham, Christopher D Lloyd, Dylan T. Garceau, Rita O’Rourke, Sarah Herrick, , Adrian L. Oblak

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

Alzheimer s & Dementia · May 12, 2024Peer-reviewedNeuroscience

A novel mouse model expressing human forms for complement receptors CR1 and CR2

Harriet M. Jackson, Kate E. Foley, Rita O’Rourke, Timothy M. Stearns, Dina Fathalla, B. Paul Morgan, Gareth R. Howell

This paper creates a mouse model expressing human CR1 and CR2 variants to study their role in disease.

BMC Genetics · Sep 9, 2020Peer-reviewedGenetics