Spatial memory in Alzheimer's disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330
Shi Quan Wong, Adia Ouellette, Laura Harrison, Avery McNamara, Rachel A. Tam, Alexander Alexandrov, Acacia Nawrocik-Madrid, Jesus J Sanchez, Brett C. Ginsburg, Arturo Andrade, Louis R. Lapierre
This study shows that XPO1 inhibitor KPT-330 improves spatial memory in Alzheimer's 5XFAD mice by reducing amyloid deposition in specific brain regions while increasing overall amyloid levels.
GeroScience · Feb 6, 2026Peer-reviewedNeuroscience