Brett C. Ginsburg

This study shows that Canagliflozin's neuroprotective effects in aging mice are sex-specific, with males benefiting more despite females having higher drug concentrations.

This study shows that XPO1 inhibitor KPT-330 improves spatial memory in Alzheimer's 5XFAD mice by reducing amyloid deposition in specific brain regions while increasing overall amyloid levels.

This study investigates how canagliflozin affects brain aging and Alzheimer's-like pathology in mice, finding sex-specific effects on hippocampal function and disease markers.

This study shows Canagliflozin improves metabolic control in aged male mice but not females, with sex-specific effects on hypothalamic gene expression and metabolic pathways.

This study shows that Canagliflozin improves central insulin sensitivity and reduces neuroinflammation in aged male mice but not females, suggesting sex-specific neuroprotective effects.