Author

Louis R. Lapierre

Brown UniversityORCID 0000-0002-8154-141XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 3 Research Focus:benchmarking· 2 Organism:C. elegans· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adia Ouellette· 2 shared Laura Harrison· 2 shared Shi Quan WongiD· 2 shared Acacia Nawrocik-MadridiD· 1 shared Alexander Alexandrov· 1 shared Arturo AndradeiD· 1 shared Avery McNamara· 1 shared Brett C. GinsburgiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetics

Adia Ouellette

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Validation of tissue-specific RNAi systems in C. elegans reveals a converging role for polyubiquitin UBQ-1/UBC in vitellogenin metabolism and lifespan

Noeli Soares Melo da Silva, Cristina Bolonyi, Adia Ouellette, Laura Harrison, Sung Youn Kim, Sandrine E. Daigle, Savannah Doucet, Louis R. Lapierre

bioRxiv · Mar 9, 2026 · PreprintGenetics

Spatial memory in Alzheimer's disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330

Shi Quan Wong, Adia Ouellette, Laura Harrison, Avery McNamara, Rachel A. Tam, Alexander Alexandrov, Acacia Nawrocik-Madrid, Jesus J Sanchez, Brett C. Ginsburg, Arturo Andrade, Louis R. Lapierre

This study shows that XPO1 inhibitor KPT-330 improves spatial memory in Alzheimer's 5XFAD mice by reducing amyloid deposition in specific brain regions while increasing overall amyloid levels.

GeroScience · Feb 6, 2026Peer-reviewedNeuroscience

AltumAge: A Pan-Tissue DNA-Methylation Epigenetic Clock Based on Deep Learning

Lucas Paulo de Lima Camillo, Louis R. Lapierre, Ritambhara Singh

AltumAge is a deep learning-based DNA methylation clock that improves age prediction accuracy and interpretability across tissues and ages.

npj Aging · Apr 19, 2022Peer-reviewedBioinformatics

Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans

Shi Quan Wong, Catherine J Ryan, Louis R. Lapierre

This study shows neuronal HLH-30/TFEB improves thermoresistance in C. elegans by inducing mitochondrial fragmentation in muscles, independent of DAF-16/FOXO.

bioRxiv · Apr 7, 2022 · PreprintGenetics