Systematic detection of amino acid substitutions in proteome reveals a mechanistic basis of ribosome errors
Ernest Mordret, Orna Dahan, Omer Asraf, Roni Rak, Avia Yehonadav, Georgina D. Barnabas, Jürgen Cox, Tamar Geiger, Ariel B. Lindner, Yitzhak Pilpel
The paper systematically detects amino acid substitutions in proteomes using mass spectrometry data and reveals that translation errors are primarily caused by codon-anticodon mispairing, with patterns influenced by ribosome velocity and evolutionary constraints.
Molecular Cell · Jul 25, 2019Peer-reviewedSystems Biology