Ernest Mordret

The paper identifies a family of over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage function, demonstrating their conservation and novel compound production.

The paper uses language models to predict novel antiphage defense proteins in Actinomycetota, discovering six new defense systems and over 45,000 uncharacterized protein families.

The paper introduces DefenseFinder, a resource for antiphage defense systems, including a web service, wiki, and databases with structure predictions.

The paper identifies novel human antiviral genes by comparing conserved antiphage systems across prokaryotes and eukaryotes.

The paper systematically detects amino acid substitutions in proteomes using mass spectrometry data and reveals that translation errors are primarily caused by codon-anticodon mispairing, with patterns influenced by ribosome velocity and evolutionary constraints.