High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency
Asaf Zviran, Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey V. Viukov, Jason Daniel Buenrostro, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, , Jacob H. Hanna
This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.
bioRxiv · Sep 7, 2017 · PreprintDevelopmental Biology