Author

Vladislav Krupalnik

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Assay:ChIP-seq· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2

Frequent Co-Authors

Jacob H. HannaiD· 5 shared Mirie ZerbibiD· 5 shared Noa NovershterniD· 5 shared Alejandro Aguilera-CastrejoniD· 4 shared Asaf ZviraniD· 4 shared Nofar MoriD· 4 shared Rada Massarwa· 4 shared Sergey V. Viukov· 4 shared

Activity by Year

2014-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersDevelopmental Biology

Jacob H. HannaORCID

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6 papers

Recent·Most cited

Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naive Pluripotency

Jonathan Bayerl, Muneef Ayyash, Tom Shani, Yair S. Manor, Ohad Gafni, Rada Massarwa, Yael Kalma, Alejandro Aguilera-Castrejon, Mirie Zerbib, Hadar Amir, Daoud Sheban, Shay Geula, Nofar Mor, Leehee Weinberger, Segev Naveh‐Tassa, , Jacob H. Hanna

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

Cell stem cell · Apr 28, 2021Peer-reviewedDevelopmental Biology

Context-dependent functional compensation between Ythdf m6A readers

Lior Lasman, Vladislav Krupalnik, Shay Geula, Mirie Zerbib, Sergey V. Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Orel Mizrahi, Shashank Sathe, Aharon Nachshon, Dan Schneir, Stefan Aigner, Archana Shankar, Jasmine R. Mueller, Noam Stern‐Ginossar, , Jacob H. Hanna

The paper investigates functional compensation among Ythdf m6A readers in mouse gametogenesis and embryonic stem cells, revealing dosage-dependent redundancy and distinct roles.

bioRxiv · Jun 3, 2020 · PreprintDevelopmental Biology

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey V. Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, , Jacob H. Hanna

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

Cell stem cell · Aug 16, 2018Peer-reviewedDevelopmental Biology

OCT4 Impedes Cell Fate Redirection By The Melanocyte Lineage Master Regulator MITF

Danna Sheinboim, Itay Maza, Iris Dror, Shivang Parikh, Vladislav Krupalnik, Rachel E. Bell, Asaf Zviran, Yusuke Suita, Ofir Hakim, Yael Mandel‐Gutfreund, Mehdi Khaled, Jacob H. Hanna, Carmit Levy

The paper shows OCT4 prevents cell fate change by blocking MITF's effects in embryonic stem cells and other differentiated cells.

Nature Communications · Oct 12, 2017Peer-reviewedDevelopmental Biology

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

Asaf Zviran, Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey V. Viukov, Jason Daniel Buenrostro, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, , Jacob H. Hanna

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

bioRxiv · Sep 7, 2017 · PreprintDevelopmental Biology

Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-differentiation with iPSC Reprogramming Factors

Itay Maza, Inbal Casoi, Sergey Viukov, Yoach Rais, Asaf Zviran, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Rada Massarwa, Noa Novershtern, Jacob Hanna

This study shows that most trans-differentiated cells derived from mouse fibroblasts using OSKM factors acquire pluripotency transiently before differentiation.

bioRxiv · Aug 23, 2014Developmental Biology