Author

Daoud Sheban

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 4 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

Jacob H. HannaiD· 5 shared Jonathan BayerliD· 4 shared Noa NovershterniD· 4 shared Sergey V. Viukov· 4 shared Alejandro Aguilera-CastrejoniD· 3 shared Mirie ZerbibiD· 3 shared Nofar MoriD· 3 shared Rada Massarwa· 3 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersDevelopmental Biology

Jacob H. HannaORCID

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Author profile →

6 papers

Recent·Most cited

Targeting proteasome composition reprograms tumor-intrinsic inflammation through selective degradation of STAT1

Merav D. Shmueli, Yongfeng Tao, Ekampreet Singh, Matthias P. Kramer, Anat Abramov, Tuval Aizik, Daoud Sheban, Arseniy A. Lobov, Karin Goldberg, Angham Ibraheem, Ronen Shteinvil, Aaron Javitt, Yishai Levin, Michael A. Schafroth, Daisuke Ogasawara, , Yifat Merbl

This study identifies a small molecule targeting PSME4, which stabilizes STAT1 and reprograms tumor inflammation, suppressing tumor growth by altering cytokine signaling.

bioRxiv · Oct 16, 2026 · PreprintCancer Biology

Human primed and naive PSCs are both competent indifferentiating into bona fide trophoblast stem cells

Sergey V. Viukov, Tom Shani, Jonathan Bayerl, Daoud Sheban, Yonatan Stelzer, Noa Novershtern, Jacob H. Hanna

The paper shows that primed human pluripotent stem cells can be converted into trophoblast stem cells by inhibiting the TGFβ pathway, producing TSCs indistinguishable from those derived from placenta or naive PSCs.

bioRxiv · May 20, 2022 · PreprintDevelopmental Biology

Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naive Pluripotency

Jonathan Bayerl, Muneef Ayyash, Tom Shani, Yair S. Manor, Ohad Gafni, Rada Massarwa, Yael Kalma, Alejandro Aguilera-Castrejon, Mirie Zerbib, Hadar Amir, Daoud Sheban, Shay Geula, Nofar Mor, Leehee Weinberger, Segev Naveh‐Tassa, , Jacob H. Hanna

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

Cell stem cell · Apr 28, 2021Peer-reviewedDevelopmental Biology

Spatio-temporal Proteomic Analysis of Stress Granule disassembly using APEX Reveals Regulation by SUMOylation and links to ALS pathogenesis

Hagai Marmor-Kollet, Aviad Siany, Nancy Kedersha, Naama Knafo, Natalia Rivkin, Yehuda Matan Danino, Thomas G. Moens, Tsviya Olender, Daoud Sheban, Nir Cohen, Tali Dadosh, Yoseph Addadi, Revital Ravid, Chen Eitan, Beata Toth Cohen, , Eran Hornstein

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

Molecular Cell · Nov 19, 2020Peer-reviewedMolecular Biology

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey V. Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, , Jacob H. Hanna

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

Cell stem cell · Aug 16, 2018Peer-reviewedDevelopmental Biology

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

Asaf Zviran, Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey V. Viukov, Jason Daniel Buenrostro, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, , Jacob H. Hanna

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

bioRxiv · Sep 7, 2017 · PreprintDevelopmental Biology