Asaf Zviran

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

The paper shows OCT4 prevents cell fate change by blocking MITF's effects in embryonic stem cells and other differentiated cells.

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

This study shows that most trans-differentiated cells derived from mouse fibroblasts using OSKM factors acquire pluripotency transiently before differentiation.